Recently, a significant effort has been made to produce and recover valuable organic chemicals from biomass. The recovery process typically involves several steps, which vary depending on the specific biomass feedstock and the desired end products. A common step upstream of the recovery process is fermentation, where microorganisms transform biomass into valuable chemicals. After fermentation, the organic chemicals produced need to be recovered from the fermentation broth–a mixture containing low concentrations of the targeted chemicals, biomass, and water. Efficiently separating the water from the targeted chemicals presents a challenge because the produced organic chemicals often have higher boiling points than water, or are non-volatile, making traditional separation methods impractical. Removing the water by evaporation or distillation is not economical since the majority of the broth is water. To develop an efficient recovery process, Liquid-Liquid Extraction (LLE) is a promising option.

Liquid-Liquid Extraction (LLE) for Efficient Organic Chemical Recovery

While distillation is a widely used separation technique for recovering organic chemicals based on differences in boiling points, its limitations in energy consumption and potential chemical degradation make it less optimal compared to other methods. To address this, Liquid-Liquid Extraction (LLE), also known as Solvent Extraction (SX), emerges as a viable alternative. LLE involves the mass transfer of the desired compounds from the aqueous phase into an immiscible organic phase, typically via counter-current contacting of the two phases. This method is useful for separating organic acids and other compounds either directly from the whole broth or after pre-treating the broth to separate less desirable components like cell mass and lignin. 

A few key advantages of LLE: 

• Lower Operating Costs: When LLE is determined to be the optimal unit of operation, it offers cost advantages over conventional distillation, especially in processes that require one or more energy-intensive distillation steps. In such scenarios, less energy is required, reducing operational expenses and enhancing cost efficiency.
•  Recovery of Higher Boiling Compounds: Liquid-liquid extraction efficiently recovers compounds with higher boiling points than water, making it ideal for processes where traditional distillation methods are impractical due to the need to boil off large amounts of water, which has an extremely high heat of vaporization.
• Extraction of Non-Volatile Components: Liquid-liquid extraction is effective in recovering non-volatile components like many hormones and nutraceuticals, which cannot be separated through vaporization. It provides a reliable solution for isolating these components, facilitating their utilization in various industrial processes.
•  Separation of Heat-Sensitive Materials: Liquid-liquid extraction is essential for separating heat-sensitive materials such as antibiotics. Unlike distillation, which involves high temperatures, this method enables separation at ambient or lower temperatures, preserving the integrity and efficacy of heat-sensitive compounds.
•  Efficient Separation of Close-Boiling Mixtures: Liquid-liquid extraction excels in separating close-boiling mixtures that challenge traditional distillation techniques. This is because LLE relies on differences in chemical structure as opposed to distillation, which employs differences in relative volatility to achieve a separation. Furthermore, by selecting an optimal solvent, the LLE process can be designed to be selective, resulting in more efficient downstream purification steps, if required. 

Overall, LLE can offer a more efficient, cost-effective, and environmentally friendly approach to recovering organic chemicals from biomass reaction processes, like fermentation, making it a preferred choice for many industrial applications.

The KARR^® Column: A Superior Extraction Column for Emulsifying Systems

Once LLE is determined to be the most economical separation method for recovering organic chemicals from fermentation broth, it is important to select the right type of extraction column based upon separation efficiency, energy consumption, cost, and throughput. Compared to other extraction technologies, agitated extraction columns offer the optimal solution due to their high efficiency and smaller footprint. 

Koch Modular offers two types of agitated extraction columns: SCHEIBEL^® and KARR^®. When separating mixtures with a relatively high-density difference between the phases and high interfacial tension, a column with rotating internals, such as the SCHEIBEL column, is the best solution. However, fermentation broths often have lower density differences and low interfacial tension and thus are easily prone to emulsification, making the KARR column the superior method due to its reciprocating type agitation. In the KARR column, the reciprocating type agitation involves a plate stack that gently moves up and down versus a rotating impeller. By doing so, the KARR column provides uniform shear mixing across the cross-section as opposed to non-uniform shear mixing found in rotating internals. By introducing uniform shear mixing, the KARR column produces a more uniform dispersed phase particle size distribution. This type of mixing has been proven to be optimal for these systems via many different applications, whereby the tendency to emulsify can be significantly reduced and even eliminated.

Designing an Efficient LLE System

When considering the addition of an LLE system into your process, the following three steps are key for a successful design:

1. Solvent Selection and Laboratory Testing: are necessary to generate the liquid-liquid equilibrium data and to evaluate the hydraulic behavior of the system. Based upon mixing and settling behavior, the selection of the KARR vs the SCHEIBEL column can often be made. 
2. Pilot Plant Testing: should be performed to generate data for accurate production equipment design. Koch Modular handles this at its pilot facility in Houston, Texas.
3. Complete System Design: downstream distillation is usually required to recover the solvents for recycling and to selectively recover and purify the chemicals of interest. It is critical to have a good understanding of the composition of the LLE feed and the final compositions of both the extract and raffinate phases leaving the extraction column so that the downstream distillation columns can be designed accordingly.

Solving the Fermentation Process

In addressing the challenge of acetic acid recovery from a fermentation broth of waste wood material, a leading biorefinery developer sought Koch Modular’s expertise. Having encountered emulsification issues and poor separation during pilot testing in a rotating disc contactor column, the client provided fermentation broth to Koch Modular for additional pilot testing.

Koch Modular successfully conducted pilot testing using a 1” diameter KARR column, achieving close to 99% extraction of acetic acid from the fermentation broth. Notably, the solvent-to-feed ratio was reduced from 2 (per the client’s estimate) to 1.5. This efficient extraction process was pivotal, surpassing the client’s expected and targeted recovery of acetic acid from the fermentation broth. 

The modular system designed by Koch Modular included the KARR column for extraction of acetic acid from the broth, a downstream raffinate stripping column, and a distillation column for generating acetic acid product and recycling the solvent back to the extraction step. The KARR column has a 22” diameter and reflected 484 times scale up from the 1” diameter column used during pilot testing.

In light of these achievements, the client progressed to the adoption of proven esterification technology for further product conversion. The esterification part of the plant transformed acetic acid into ethyl acetate, a valuable salable product and the chemical precursor crucial for the client’s cellulosic ethanol production. This collaborative effort demonstrates the practical application of innovative solutions in addressing challenges associated with biorefinery processes.

Conclusion

The integration of LLE, especially with column designs like KARR, proves instrumental in addressing the complexities of biomass processing, offering economic viability, sustainability, and breakthroughs in organic chemical recovery. The acetic acid extraction case study exemplifies the successful application of LLE to mitigate unique separations challenges as well as emphasizing the critical steps required in designing an efficient LLE system, from solvent selection and laboratory testing to pilot plant testing and complete system design. 

Authors

Chat with Don
Don Glatz is the Manager of Extraction Technology at Koch Modular. With a remarkable career spanning over 47 years, Don is an expert in evaluating, optimizing, scaling, and designing extraction processes. His profound knowledge and experience have been shared through numerous published papers and articles. Don holds a Bachelor’s degree in Chemical Engineering from Rensselaer Polytechnic Institute, complemented by an MBA from Fairleigh Dickinson University. His invaluable contributions continue to shape the field of extraction technology.

Email: donald.glatz@kochmodular.com

Chat with Brendan
Brendan Cross is a Principal Extraction Engineer at Koch Modular that works in the Extraction Technology Group. Brendan is responsible for liquid-liquid extraction application evaluation, extraction process development, and pilot test design, extraction column design, and commissioning & process startup. He has been with Koch Modular for 15 years and also has substantial experience in distillation and process design. Brendan holds a BS in chemical engineering from Columbia University.

Email: brendan.cross@kochmodular.com

The post Revolutionizing Biomass Processing: Unlocking the Potential of Liquid-Liquid Extraction (LLE) in Organic Chemical Recovery appeared first on Koch Modular Process System.

PARAMUS, N.J., March 15, 2024—Koch Modular Process Systems (Koch Modular), a leading provider of engineered and fabricated modular mass transfer systems for the chemical processing industry, proudly announces its recognition and ranking on The Daily Digest’s esteemed list of the 50 Hottest Companies in the Bioeconomy 2024.

The Daily Digest revealed the rankings at the Advanced Bioeconomy Leadership Conference 2024 in Washington, D.C. The annual rankings, which recognize innovation and achievement in fuels and integrated biorefinery development, are based on votes from an invited panel of distinguished international selectors and subscribers of The Digest. This accolade celebrates Koch Modular’s exceptional contributions to the bioeconomy’s development and project deployment.

“This year, the voters went jet in picking companies from all around the world focused on sustainable aviation fuels and chemicals — founded in India, New Zealand, the US, the UK, in the top 10,” said Digest editor and publisher Jim Lane.

With a commitment to innovation and excellence, Koch Modular advances clean-tech through unparalleled expertise in process engineering, distillation and liquid-liquid extraction technology, pilot testing, and modular project delivery models. The company empowers businesses to reduce costs, streamline project timelines, and enhance project viability with scalable, repeatable, fixed-price modular designs.

“We are honored to be recognized as one of The Daily Digest’s 50 Hottest Companies in the Bioeconomy 2024,” said Brian Loftus, Vice President at Koch Modular. “This achievement underscores our dedication to advancing sustainability technologies and our ongoing commitment to driving innovation in the chemical processing industry.”

The Daily Digest’s 50 Hottest Companies in the Bioeconomy 2024 award exemplifies Koch Modular’s leadership and dedication to driving sustainable solutions within the bioeconomy.

Find the full list of award winners HERE.

About Koch Modular

Koch Modular has successfully designed and constructed modular systems for the global chemical processing industry for over 25 years and has over 40 years of process engineering experience. Specializing in mass transfer, Koch Modular supports innovative technology companies on their pathway from concept to commercialization, providing pilot testing and process conceptualization services, process design package development, detailed engineering, and modular constructed systems. To learn more, visit kochmodular.com.

Contacts

Emily Steinhauer
CG Life
esteinhauer@cglife.com

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Join Koch Modular at this year’s Advanced Bioeconomy Leadership Conference (ABLC NEXT 2022) in San Francisco on October 26^th-28^th. ABLC Next is a connected series of conferences and events focused on today’s critical issues within the bioeconomy, including renewable chemicals, materials, and fuels.

As a dedicated partner within the biochemical and biodiesel industry, Koch Modular collaborates with emerging technology companies that address these important challenges head-on. With 40+ years of experience, the company’s experienced engineers strive to solve the most complex separation problems within the product purification, organic chemical separations, solvent recovery, renewable energy production, stream stripping, wastewater treatment, solvent drying, and acid gas removal industries. Koch Modular is a crucial innovation partner from early concept to modular delivery of the first pilot, demo, or commercial-scale process system. 

“Virtually every new production system will require separation and purification at some point within the process. We are one of the only engineering companies that can offer a guarantee on product purity,” states Chris Rentsch, Process Development Manager at Koch Modular.

Tom Schafer, Vice President of Koch Modular sat down with Process-Worldwide to explain that “Today, the industry is shifting away from our dependence on the future use of petroleum-based feedstocks and demanding projects which support decarbonization. Scalability and repeatable design characteristics are a must when bringing decarbonization projects to the market.” Modular plants are addressing the needs within the industry. “A modular plant delivery model will play an important and strategic role in delivering tomorrow’s projects,” Schafer added. 

With clients such as PureCycle Technologies, Origin Materials, Bluescape and Regen III, Koch Modular is eager to share its expertise and real-life experience with separation technology and applications within the chemical processing industry. 

Stop by booth #14 to chat with one of our experienced engineers. 

Find more information about ABLC Next 2022 HERE.

Chat with Tom

Tom Schafer has 38 years of experience in process design, operations management, cost estimating, plant layout, and sales & marketing. Specific expertise in equipment design, including distillation, heat transfer, fluid flow, and process control. Tom holds a B.S. in Chemical Engineering and an M.S. in Chemical Engineering from Manhattan College.

Email: tom.schafer@kochmodular.com

Chat with Chris

Chris Rentsch has over 15 years of experience working with developing technology companies as well as established chemical industries, which includes numerous international plant start-up assignments. He is responsible for process development and overall design and operating parameters of chemical plant process systems. Chris holds a BS in Chemical Engineering from the University of Michigan

Email: chris.rentsch@kochmodular.com

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Challenges of Extracting Carboxylic Acid from Aqueous Fermentation Broth

When extracting carboxylic acids from an aqueous fermentation broth generated in a cellulosic ethanol process, using ethyl acetate as the solvent of choice, initial attempts by the end user to develop the LLE process step in a rotating disc contactor (RDC) proved to be unsatisfactory.

Solving Emulsification Issues with the KARR® Column

Poor product recovery (< 90%) and a high solvent to feed ratio required (≥ 1.7) were not acceptable. The end user knew that the process had a high tendency towards emulsification. Armed with this information, Koch Modular tested the process in a 25 mm diameter KARR® Column. The KARR® Column demonstrated excellent operability, generating fine dispersion of the solvent phase at low agitation speed as expected for systems which tend to emulsify.

How Did the KARR® Column Perform?

Results?
• The solvent to feed ratio was improved to 1.5.
• The acid recovery was increased to 98-99% at slightly elevated temperature (40-45 oC).

With many more stories to share and solve for our clients, we are always happy to hear from you! If you’ve got a difficult separations problem, please send an email to contact@kochmodular.com or call us at +1 201 267 8670.

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Recovering Valuable Products from Biomass via Liquid-Liquid Extraction (LLE)

Liquid-Liquid Extraction (LLE) is an ideal unit operation for the removal of many of these compounds either directly from the broth itself (whole broth) or from the broth after some pre-treatment step to separate the less desirable components such as cell mass, lignin, etc.

Many biomass systems, especially those produced by fermentation processes or by algae ponds demonstrate a tendency towards emulsification upon contact with the extraction solvent.

KARR® Column to the Rescue

Years of experience have shown that the reciprocating type agitation used by a KARR® Column is superior to rotating internals for systems that have a tendency to emulsify². Selection of the column type is critical in order to optimize the performance and cost for the extraction process.

Liquid-Liquid Extraction Design Requirements

Three steps to a complete system design include:

1. Solvent Selection and Laboratory Testing are necessary to generate the liquid-liquid equilibrium data and to evaluate the hydraulic behavior for the system.
2.  Pilot Plant Testing should be performed to generate data for accurate design of production equipment. Koch Modular handles this at its pilot facility in Texas.
3. Complete System Design: Downstream distillation is usually required to recover the solvents for recycle and to selectively recover and purify the chemicals of interest. It is critical to have a good understanding of the composition of the LLE feed as well as the final compositions of both the extract and raffinate phases leaving the extraction column so that the distillation columns can be designed accordingly.

Bring your toughest biomass challenges to discuss at our booth at ACHEMA next month. We will have an extraction column on site and our subject matter expert, Don Glatz, is available for detailed technical conversations.

The post Fermentation in Your Process? appeared first on Koch Modular Process System.

While large CPI projects are a big part of what we do, our team here at Koch Modular really digs in when a developing technology comes our way.

The creative development of a process pathway gets chemical engineers energized. Koch Modular has A LOT of chemical engineers with decades of experience, plus project managers, mechanical and process controls engineers, and civil engineers. We’re a team that has worked together for twenty-five years, designing solutions with our unparalleled separations expertise and modular construction know-how.

Do You Want To Convert Biomass To Fuel? Are You Seeking Brand-New Chemical Conversion For A Biochemical Product?

Developing tech knows a lot about their own stoichiometry, knows which catalyst works and why, and deeply understands their kinetics, inside and out! Yet, until they got to know us, our developing technology clients did not know they needed Koch Modular’s expertise.

Now, our developing technology clients often come to us with just conceptual chemical processes – and stay for the collaboration.

Why Choose Koch Modular Chemical Processing Equipment?

Koch Modular understands that developing technology companies require expertise that goes beyond a scale-able process design. When you are an early stage technology company, you need an engineering firm with the time and patience to work side-by-side with you, making sure that timelines are set and reality checks are woven in along the way. We start with discussions on concept development, followed by technical and commercial modeling, detailed design, construction, and even plant start-up, resulting in successful first production. This can be a longer process not easily tolerated by larger engineering firms.

To go from a chemical process idea to fully functional manufacturing reality means looking out years into the future.

Koch Modular is ready to listen.

Talk to the Engineering Firm that Listens.

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Every puzzle has a solution, if you know where to look.

How Koch Modular designed a Modular Acetic Acid Recovery and Purification System

Koch Modular knows the answers to liquid-liquid extraction puzzle. We designed a modular acetic acid recovery and purification system, using liquid-liquid extraction,distillation and wastewater stripping as the three essential mass transfer processes. Koch Modular’ss Houston, TX pilot plant delivered successful pilot plant results, using the KARR® Column, a Koch Modular proprietary liquid-liquid extraction technology, proving that we could meet recovery specifications and required production rates.

The reciprocating action of the plate stack internals that are part of the proprietary KARR® Column, solved the puzzle of the emulsification problem.

And then things really got moving!

Putting KARR® Columns Into Action

The modules were delivered to the site just 34 weeks after detailed engineering began. Our solvent recovery experience, liquid-liquid extraction technology and modular construction experience resulted in a successful start-up that met all performance specifications.

Koch Modular provided a Process Performance Guarantee. Based on client-provided production rates and the aforementioned pilot testing, the client’s recovery specifications were guaranteed, giving our client the confidence to move decisively.

And they say nothing in life is guaranteed……unless you’re working with Koch Modular. 

The full WhitePaper for this acetic acid recovery process can be found here in our SlideShare.

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